منابع مشابه
Water influx into cerebrospinal fluid is primarily controlled by aquaporin-4, not by aquaporin-1: 17O JJVCPE MRI study in knockout mice
Recent studies on cerebrospinal fluid (CSF) homeostasis emphasize the importance of water flux through the pericapillary (Virchow-Robin) space for both CSF production and reabsorption (Oreskovic and Klarica hypothesis), and challenge the classic CSF circulation theory, which proposes that CSF is primarily produced by the choroid plexus and reabsorbed by the arachnoid villi. Active suppression o...
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متن کاملAquaporin Evolution in Fishes
Aquaporins represent a primordial group of transmembrane solvent channels that have been documented throughout the living biota. This facet alone emphasizes the positive selection pressure for proteins associated with intracellular fluid homeostasis. Amongst extant Eukaryota the highest gene copy number can be found in plants and teleosts, a feature that reflects the genomic duplication history...
متن کاملThe aquaporin water channels.
The topic of my talk, the aquaporins, is something that we have been studying in our lab for the last 15 years. It is not something that I anticipated when starting my career. In fact, I am a hematologist, but in science, sometimes what we find is not what we are looking for. A typical middle-aged man, I weigh 75 kg, of which 50 are water. This is something that we all share. Water is the major...
متن کاملAquaporin Protein-Protein Interactions
Aquaporins are tetrameric membrane-bound channels that facilitate transport of water and other small solutes across cell membranes. In eukaryotes, they are frequently regulated by gating or trafficking, allowing for the cell to control membrane permeability in a specific manner. Protein-protein interactions play crucial roles in both regulatory processes and also mediate alternative functions s...
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ژورنال
عنوان ژورنال: Lab Animal
سال: 2017
ISSN: 0093-7355,1548-4475
DOI: 10.1038/laban.1205